August 31, 2016


Jeffrey FriedmanLasker Award Session

Leptin and the Hypothalamic Circuitry Controlling Feeding and Glucose Metabolism
Rockefeller University, New York, USA
Howard Hughes Medical Institute, Georgia, USA


Dr. Jeffrey Friedman is a physician scientist studying the genetic mechanisms that regulate body weight. Dr. Friedman’s research on various aspects of obesity received national attention in late 1994, when it was announced that he and his colleagues had isolated the mouse ob gene and its human homologue. They subsequently found that injections of the encoded protein, leptin, decreases body weight of mice by reducing food intake and increasing energy expenditure. Current research is aimed at understanding the genetic basis of obesity in human and the mechanisms by which leptin transmits its weightreducing signal.

After completing a residency in Internal Medicine at Albany Medical Center Hospital, Dr. Friedman came to Rockefeller as a postgraduate fellow and associate physician in 1980. From 1980 to 1981, he also served as a postgraduate fellow at Cornell University Medical College. In 1986, he received a Ph.D. under the tutelage of Professor James E. Darnell, was appointed assistant professor, and became an assistant investigator at the Howard Hughes Medical Institute.

He is currently a Professor at the Rockefeller University, an Investigator at the Howard Hughes Medical Institute and the Director of the Starr Center for Human Genetics. His work led him to be recognized with many prestigious awards, such as the 2005 Canada Gairdner Award and the 2010 Albert Lasker Basic Medical Research Award for his discovery of the hormone leptin.

Location: New York, USA

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