Uniting the genome: a novel role of piRNA in the Germline
Director at the Yale Stem Cell Center
Professor of Cell Biology, of Genetics, and of Obstetrics, Gynecology, and Reproductive Sciences, Haifan Lin is Founding Director of Yale Stem Cell Center. Dr. Lin’s work is focused on the self-renewing mechanism of stem cells, using Drosophila germline stem cells, mouse germline and embryonic stem cells, human embryonic stem cells, and Hydra stem cells as models. He also studies germline development and stem cell-related cancers.
Dr. Lin has made key contributions to the demonstration of stem cell asymmetric division and the proof of the stem cell niche theory. He discovered the Argonuate/Piwi gene family and their essential function in stem cell self-renewal and germline development. He is also a discoverer of a novel class of non-coding small RNAs called PIWI-interacting RNAs (piRNAs), which was hailed by the Science Magazine as one of the Ten Scientific Breakthroughs in 2006. More recently, he proposed and demonstrated the crucial roles of the Piwi-piRNA pathway in epigenetic programming and in posttranscriptional regulation of mRNA and lncRNA.
Dr. Lin has provided numerous services to the scientific community and beyond and is currently working as editor of several international scientific publications.
For his achievements, Professor Haifan Lin has received many awards and honors, such as the 2015 Research Award by the Society for the Study of Reproduction and the 2012 National Institutes of Health Merit Award.
Location: New Haven, USA